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MYC Amplification in Angiosarcoma Arising from an Arteriovenous Graft Site
Kristen M Paral1, Gordana Raca2, Thomas Krausz3
1Department of Medicine, Section of Dermatology, University of Chicago, 5841 S Maryland Avenue, MC 5067, Chicago, IL 60637, USA.
Abstract:
Angiosarcoma arising in association with an arteriovenous graft (AVG) or fistula is a unique clinicopathologic scenario that appears to be gaining recognition in the literature. Among reported cases, none has described high-level MYC gene amplification, a genetic aberration that is increasingly unifying the various clinicopathologic subdivisions of angiosarcoma. We therefore report the MYC gene status in a case of angiosarcoma arising at an AVG site.
