Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...

Insulin Formulations: Types and Delivery

Insulin Formulations: Types and Delivery

Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into...

Intrauterine Drug Delivery Systems

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pre-operative anaemia, intra-operative hepcidin concentration and acute kidney injury after cardiac surgery: a retrospective observational study.

Anaesthesia·2018

Same author

Exosomal Fetuin-A identified by proteomics: a novel urinary biomarker for detecting acute kidney injury.

Kidney international·2006

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 28, 2026

Author Spotlight: Enhancing Microinjection Needle Quality by Wet Beveling

Author Spotlight: Enhancing Microinjection Needle Quality by Wet Beveling

Published on: September 27, 2024

Needle free injection technology: A complete insight.

Ansh Dev Ravi¹, D Sadhna², D Nagpaal¹

¹Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India.

International Journal of Pharmaceutical Investigation

|December 19, 2015

Summary

Needle-free injection technology (NFIT) offers a safe alternative to traditional needles, utilizing various forces for drug delivery. This innovation is crucial for mass immunization and pharmaceutical advancements, minimizing needle-stick injuries.

Keywords:

Immunization needle stick injuries propel sterility syringe systems

More Related Videos

Author Spotlight: A Novel Cell Injection Method with Minimum Invasion

Author Spotlight: A Novel Cell Injection Method with Minimum Invasion

Published on: April 21, 2023

Microinjectrode System for Combined Drug Infusion and Electrophysiology

Microinjectrode System for Combined Drug Infusion and Electrophysiology

Published on: November 13, 2019

Related Experiment Videos

Last Updated: Mar 28, 2026

Author Spotlight: Enhancing Microinjection Needle Quality by Wet Beveling

Author Spotlight: Enhancing Microinjection Needle Quality by Wet Beveling

Published on: September 27, 2024

Author Spotlight: A Novel Cell Injection Method with Minimum Invasion

Author Spotlight: A Novel Cell Injection Method with Minimum Invasion

Published on: April 21, 2023

Microinjectrode System for Combined Drug Infusion and Electrophysiology

Microinjectrode System for Combined Drug Infusion and Electrophysiology

Published on: November 13, 2019

Area of Science:

Drug Delivery Systems
Biomedical Engineering
Pharmaceutical Technology

Background:

Needle-free injection technology (NFIT) encompasses diverse drug delivery systems that bypass hypodermic needles.
NFIT is valuable for mass immunization programs, reducing needle-stick injuries and complications from reused needles.

Purpose of the Study:

To provide a comprehensive overview of needle-free injection technology.
To highlight the benefits and applications of NFIT in pharmaceuticals and global health.

Main Methods:

Classification of NFIT devices based on working principles, load type, drug delivery mechanism, and delivery site.
Discussion of critical factors for effective drug administration, including drug sterility, shelf life, and viscosity.
Overview of manufacturing techniques, primarily injection molding.

Main Results:

NFIT systems can administer highly viscous drugs unsuitable for traditional needles.
Several NFIT devices are commercially available, with FDA clearance, indicating significant market investment and acceptance.
The technology offers advantages for both the pharmaceutical industry and developing nations.

Conclusions:

Needle-free injection technology represents a significant advancement in drug delivery, offering enhanced safety and efficacy.
The versatility and technical superiority of NFIT position it for widespread adoption in healthcare and pharmaceutical applications.