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Related Experiment Video

Updated: Mar 28, 2026

Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography
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[Technical principles of OCT angiography].

P P Fang1, W M Harmening1, P L Müller1

  • 1Universitäts-Augenklinik Bonn, Ernst-Abbe-Str. 2, 53127, Bonn, Deutschland.

Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft
|December 20, 2015
PubMed
Summary

Optical coherence tomography angiography (OCT-A) provides non-invasive, 3D visualization of retinal and choroidal vasculature. This advanced OCT technology enables detailed perfusion analysis and is now clinically applicable for detecting vascular alterations.

Keywords:
AngiographyChoroidImagingOcular blood circulationRetina

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Angiography

Background:

  • Optical coherence tomography angiography (OCT-A) is an advanced, non-invasive imaging technique.
  • It visualizes retinal and choroidal vascular structures in 3D without contrast dyes.
  • OCT-A builds upon OCT technology, enabling both morphological and perfusion analyses.

Purpose of the Study:

  • To discuss the principles and applications of OCT-A.
  • To compare OCT-A with other non-invasive diagnostic devices for retinal and choroidal circulation.
  • To highlight the clinical utility of OCT-A.

Main Methods:

  • Selective literature review.
  • Analysis of own data.

Main Results:

  • OCT-A offers easy application, avoiding mydriasis and dye injections.
  • It provides precise 3D localization of vascular changes.
  • Software segmentation in retinal pathologies may differ from actual retinal architecture, requiring clinical consideration.

Conclusions:

  • OCT-A is the only non-invasive device currently suitable for routine clinical use in visualizing retinal and choroidal circulation.
  • This technology allows depth-selective visualization of alterations.
  • OCT-A overcomes masking effects like pooling or staining seen with other methods.