Related Experiment Video
Updated: Mar 28, 2026

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
Published on: March 17, 2020
Weight Loss and Decrease of Body Mass Index during Allogeneic Stem Cell Transplantation Are Common Events with
Christina T Rieger1, Isabel Wischumerski1, Christian Rust2
1Department of Internal Medicine III, Klinikum der Universität München, Munich, Germany.
Weight loss is common during allogeneic stem cell transplantation (SCT), even with total parenteral nutrition (TPN). However, significant weight loss (≥5% BMI) did not negatively impact transplant outcomes or survival.
Area of Science:
- Hematology
- Oncology
- Transplantation Medicine
Background:
- Cancer patients often experience significant morbidity and mortality due to weight loss.
- Allogeneic stem cell transplantation (SCT) frequently impairs oral nutrition, necessitating total parenteral nutrition (TPN).
Purpose of the Study:
- To investigate weight changes during SCT and their clinical consequences.
- To assess the impact of weight loss on patient outcomes after SCT.
Main Methods:
- Analysis of 180 consecutive patients undergoing allogeneic SCT.
- Evaluation of weight loss, laboratory parameters, and clinical data.
Main Results:
- Median BMI decreased by 6.6% during SCT, with 55.6% of patients experiencing ≥5% weight loss.
- Malnutrition increased significantly (28.3% to 45.0%) despite TPN.
- No meaningful difference in side effects or survival was observed between patients with and without significant weight loss.
Conclusions:
- Weight loss is frequent during allogeneic SCT, even with TPN.
- A decrease in BMI ≥5% did not significantly affect transplant outcomes, side effects, or survival.
More Related Videos
11:55Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
Published on: March 14, 2011
06:28Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis
Published on: November 10, 2023
Related Concept Videos
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
Tissue Transplantation
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Regulation of Hematopoietic Stem Cells
Stem Cell Therapy for Tissue Regeneration
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Kidney Transplant I: Introduction