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Metoprolol-controlled release, zero order kinetics.

M J Kendall1

  • 1Department of Pharmacology, Medical School, Birmingham, UK.

Journal of Clinical Pharmacy and Therapeutics
|June 1, 1989
PubMed
Summary
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Metoprolol CR/ZOK offers continuous therapeutic plasma concentrations for hypertension and angina. This beta-1 blocker formulation ensures effective, well-tolerated treatment and secondary prevention after myocardial infarction.

Area of Science:

  • Pharmacology and Pharmaceutical Sciences
  • Cardiovascular Medicine

Background:

  • Metoprolol is a widely used beta-1 selective beta-blocker.
  • Existing formulations may not provide consistent plasma concentrations.

Purpose of the Study:

  • To review the development and pharmacology of Metoprolol CR/ZOK.
  • To assess the efficacy and tolerability of this new formulation.

Main Methods:

  • Review of pharmaceutical development and pharmacological data.
  • Comparative assessment of efficacy and tolerability.

Main Results:

  • Metoprolol CR/ZOK is designed for continuous, zero-order release.
  • This formulation aims for consistent therapeutic plasma levels.

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Conclusions:

  • Metoprolol CR/ZOK presents a potentially improved treatment option for hypertension and angina.
  • It is indicated for secondary prevention post-myocardial infarct with good tolerability.