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Mechanisms involved in triggering rheumatoid arthritis
Anca I Catrina1, Vijay Joshua1, Lars Klareskog1
1Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
Immunological Reviews
|December 20, 2015
Summary
Rheumatoid arthritis (RA) involves autoimmune responses targeting joints, triggered by modified proteins. Understanding these immune processes aids early diagnosis and prevention strategies for RA.
Area of Science:
- Immunology
- Rheumatology
- Autoimmune Diseases
Background:
- Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease.
- RA pathogenesis involves autoantigens, including citrullinated proteins, and genetic predisposition.
- Immune responses in RA share similarities with other autoimmune conditions, with pathogenic responses preceding clinical onset.
Purpose of the Study:
- To review the iterative processes of innate and adaptive immunity in the development of RA.
- To explore how post-translational modifications trigger autoimmune reactions in RA.
- To highlight the potential for earlier diagnosis and prevention of RA through better understanding of immune mechanisms.
Main Methods:
- This review synthesizes current research on the immunological mechanisms underlying RA development.
- Focuses on the interplay between innate and adaptive immunity.
- Examines the role of autoantigens and genetic susceptibility.
Main Results:
- Autoantigens in RA are post-translationally modified proteins, often citrullinated.
- Innate immune stimuli can trigger autoimmune reactions in genetically susceptible individuals.
- Chronic joint inflammation results from the interplay of innate and adaptive immunity.
Conclusions:
- Understanding the longitudinal development of immune reactions is crucial for RA.
- Earlier diagnosis and identification of at-risk individuals are possible through studying these processes.
- This knowledge opens avenues for RA prevention strategies.
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