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Updated: Mar 28, 2026
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Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
Published on: September 15, 2023
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Surgically Treated Pediatric Nonpapillary Thyroid Carcinoma
Samuel Golpanian1, Jun Tashiro1, Juan E Sola1
1Department of Pediatric Surgery, University of Miami, Miami, Florida, United States.
Summary
Pediatric nonpapillary thyroid cancer incidence is low, with females having higher rates but similar survival to males. For medullary thyroid cancer, only disease stage independently predicts survival.
Area of Science:
- Pediatric Oncology
- Endocrinology
- Cancer Epidemiology
Background:
- Pediatric thyroid carcinoma (PTC) is rare, with nonpapillary subtypes requiring specific outcome analysis.
- Understanding survival predictors in pediatric nonpapillary thyroid cancer is crucial for treatment optimization.
Purpose of the Study:
- To update survival outcomes and identify prognostic factors for pediatric nonpapillary thyroid carcinoma.
- To analyze demographic and clinical characteristics of this rare pediatric cancer population.
Main Methods:
- Utilized the Surveillance, Epidemiology, and End Results (SEER) database for pediatric cases (<20 years) of surgically treated nonpapillary thyroid carcinoma (1973-2011).
- Included follicular, medullary, Hürthle-cell, and nonencapsulated sclerosing carcinoma subtypes.
- Analyzed demographics, clinical features, and survival using statistical methods.
Main Results:
- Identified 493 cases; overall incidence was 0.096/100,000 person-years.
- Mean age 15 years; higher incidence in white females aged 15-19 years.
- Overall 30-year survival was 91%, higher in females (94%) and localized disease (92%). Stage was the sole independent predictor for medullary thyroid cancer.
Conclusions:
- Pediatric nonpapillary thyroid cancer has a low incidence.
- Females exhibit higher incidence but comparable survival rates to males.
- Disease stage is the primary independent prognostic indicator for medullary thyroid cancer survival.
