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Busulfan lung.

American Journal of Diseases of Children (1960)

|June 1, 1977

Summary

This summary is machine-generated.

Busulfan therapy for chronic myelogenous leukemia can cause fatal pulmonary fibrosis, known as "busulfan lung." This report details the first pediatric case in a 16-month-old infant, highlighting the drug

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Area of Science:

Pediatric Oncology
Pulmonary Medicine
Toxicology

Background:

Busulfan is a chemotherapy agent used for chronic myelogenous leukemia.
Pulmonary fibrosis is a rare but lethal side effect of busulfan therapy.

Observation:

A 16-month-old infant received busulfan for 11 months.
The infant developed progressive lung changes consistent with diffuse intra-alveolar and interstitial fibrosis.
The patient experienced acute respiratory distress and expired.

Findings:

Histological examination revealed characteristic busulfan-induced lung and pancreatic changes.
Autopsy excluded infection or leukemic infiltration as causes of lung pathology.
This case represents the first reported instance of busulfan lung in a pediatric patient.

Implications:

Highlights the potential for busulfan-induced pulmonary toxicity in pediatric patients.
Emphasizes the need for vigilant monitoring of lung function in children undergoing busulfan therapy.
Underscores the importance of considering drug-induced lung disease in pediatric respiratory failure.