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Aetiology of Paediatric End-stage Renal Failure in Jordan: A Multicentre Study

K F Akl1, J H Albaramki2, I Hazza3

  • 1College of Medicine, The University of Jordan, Amman, Jordan,

The West Indian Medical Journal
|December 20, 2015
PubMed

Insights

Congenital anomalies of the kidney and urinary tract (CAKUT) were the leading cause of end-stage renal failure (ESRF) in Jordanian children. This study highlights the critical need for understanding ESRF aetiology in pediatric populations.

Area of Science:

  • Pediatric Nephrology
  • Renal Replacement Therapy
  • Public Health

Background:

  • End-stage renal failure (ESRF) in children presents a significant global health challenge.
  • Understanding the specific aetiologies of pediatric ESRF is crucial for developing targeted prevention and treatment strategies.
  • Jordanian data on the causes of pediatric ESRF were previously limited.

Purpose of the Study:

  • To determine the primary causes of end-stage renal failure (ESRF) in children within Jordan.
  • To analyze the distribution of different aetiologies contributing to pediatric ESRF.
  • To provide baseline data for future research and clinical interventions in pediatric nephrology in Jordan.

Main Methods:

  • A multicentre retrospective study was conducted across five hospitals in Jordan.
  • Medical records of 275 children diagnosed with ESRF were reviewed.
  • Data collected included patient demographics, aetiology of ESRF, renal replacement therapy (RRT) modality, and patient outcomes.

Main Results:

  • Congenital anomalies of the kidney and urinary tract (CAKUT) were the most frequent cause of ESRF (45.8%).
  • Heredofamilial disorders (23.2%) and glomerulopathies (26.2%) were the next most common aetiologies.
  • The study also detailed specific conditions within these categories, such as neurogenic bladder and focal segmental glomerulosclerosis, and reported on RRT modalities and associated mortality rates.

Conclusions:

  • This study provides the first comprehensive report on the aetiology of ESRF in children in Jordan.
  • CAKUT, heredofamilial disorders, and glomerulopathies are the predominant causes of pediatric ESRF in the region.
  • Findings underscore the importance of addressing these specific aetiologies in pediatric kidney care in Jordan.
Abstract

Keywords:
AetiologyJordanchildrenchronic kidney diseaseend-stage renal failure

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