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Parecoxib sodium reduces the need for opioids after tonsillectomy in children: a double-blind placebo-controlled

Xiuze Li1, Mengjun Zhou2, Qing Xia3

  • 1Department of Anesthesiology, Mianyang Central Hospital, 12 Changjia Lane, Mianyang, 621000, Sichuan, China. lxz123@126.com.

Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie
|December 20, 2015
PubMed

Insights

Intravenous parecoxib sodium effectively manages pediatric tonsillectomy pain, reducing the need for morphine and lowering the incidence of postoperative nausea and vomiting (PONV). This treatment offers significant pain relief for children undergoing the procedure.

Area of Science:

  • Pediatric Anesthesiology
  • Pain Management
  • Pharmacology

Background:

  • Postoperative pain is a significant concern following pediatric tonsillectomy.
  • Effective pain management strategies are crucial for patient recovery and well-being.

Purpose of the Study:

  • To evaluate the analgesic efficacy of intravenous parecoxib sodium in children undergoing tonsillectomy.
  • To compare parecoxib sodium with placebo in terms of pain control and adverse effects.

Main Methods:

  • A prospective randomized double-blind placebo-controlled trial involving 60 children aged 3-7 years.
  • Participants received either intravenous parecoxib sodium (1 mg·kg⁻¹) or saline post-anesthesia induction.
  • Outcomes measured included rescue morphine requirements, time to first analgesic, pain scores, and adverse events like PONV.

Main Results:

  • Fewer children receiving parecoxib sodium required rescue morphine (57% vs. 83% for placebo).
  • The time to the first rescue analgesic was significantly longer in the parecoxib group (193 min vs. 132 min).
  • Parecoxib sodium reduced pain scores and the incidence of postoperative nausea and vomiting (PONV).

Conclusions:

  • Intravenous parecoxib sodium (1 mg·kg⁻¹) is an effective analgesic for pediatric tonsillectomy.
  • It demonstrates a morphine-sparing effect and reduces PONV.
  • This intervention improves postoperative pain control in pediatric patients.
Abstract

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