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Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners.
1Professor Emeritus, Nagoya University, 1204 Hirabariminami 2, Tenpaku, Nagoya 468-0020, Japan tmurama@med.nagoya-u.ac.jp.
Journal of Biochemistry
|December 20, 2015
Summary
Basigin (CD147) is a crucial glycoprotein involved in nutrient transport, immune cell migration, and disease pathogenesis. Its diverse roles stem from interactions with various proteins and its function as a receptor for key molecules.
Area of Science:
- Molecular Biology
- Cell Biology
- Immunology
Background:
- Basigin (CD147/EMMPRIN) is an immunoglobulin superfamily transmembrane glycoprotein with multiple isoforms.
- It functions as a receptor for cyclophilins, S100A9, platelet glycoprotein VI, and the rod-derived cone viability factor.
- Basigin interacts with monocarboxylate transporters, GLUT1, CD44, and CD98, influencing their cell surface activity.
Purpose of the Study:
- To elucidate the multifaceted roles of basigin in physiological processes and disease.
- To detail the molecular interactions and functions of basigin and its isoforms.
- To highlight basigin's significance in various pathologies, including cancer and malaria.
Main Methods:
- Bioinformatic analysis of basigin structure and interactions.
- Review of literature on basigin's molecular recognition and functional consequences.
- Integration of data on basigin's involvement in physiological and pathological contexts.
Main Results:
- Basigin mediates nutrient transport, inflammatory leukocyte migration, and matrix metalloproteinase induction through molecular recognitions.
- Basigin is essential for vision and spermatogenesis.
- Basigin acts as a receptor for RH5, a malaria parasite protein, indicating its role in infection.
Conclusions:
- Basigin is a versatile protein with critical roles in normal physiology and disease.
- Understanding basigin's interactions is key to developing therapeutic strategies for cancer and infectious diseases.
- Further research into basigin's functions will uncover new therapeutic targets.
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