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Updated: Mar 28, 2026

Semi-Quantitative Determination of Dopaminergic Neuron Density in the Substantia Nigra of Rodent Models using Automated Image Analysis
Published on: February 2, 2021
[Comparison of Quantitative Value of Dopamine Transporter Scintigraphy Calculated from Different Analytical Software]
Masahiro Miyai1, Yasushi Yamamoto, Taku Uchibe
1Department of Radiology, Shimane University Hospital.
Abstract:
In the dopamine transporter scintigraphy there are two quantitative analysis softwares, DaTView and DaTQUANT. The quantitative value of both software has to be treated independently because there is a difference between them in the point of how to set the region of interest on the striatum and the background, calculation formula of quantitation. And also DaTQUANT has a capability of performing anatomical standardization which DaTView does not have. The aim of this study was to evaluate the accuracy of registration on DaTQUANT using a phantom, and to evaluate the correlation between the quantitative values between DaTView and DaTQUANT using clinical data. As a result, the accuracy of registration was acceptable. Regardless of the degree of accumulation in the striatum, there was a high correlation to each analysis software (r>0.85).
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