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The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
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Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
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Biocompatible cellulose-based superabsorbent hydrogels with antimicrobial activity.

Na Peng1, Yanfeng Wang2, Qifa Ye2

  • 1Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Wuhan 430071, China; Guangzhou Sugarcane Industry Research Institute, Guangzhou 510316, China.

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Summary

Novel cellulose-based hydrogels offer improved superabsorbent properties, mechanical strength, and antimicrobial activity for safer disposable diapers. These advanced hydrogels address limitations of current materials, reducing skin allergy risks.

Keywords:
Antimicrobial activityBiocompatibleCellulose hydrogelSuperabsorbent property

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Area of Science:

  • Materials Science
  • Biotechnology
  • Polymer Chemistry

Background:

  • Conventional superabsorbent hydrogels in disposable diapers exhibit poor mechanical strength, biocompatibility, and lack antimicrobial properties, potentially causing skin allergies.
  • Existing hydrogels require enhancement to meet the demands of safe and effective hygienic products.

Purpose of the Study:

  • To develop novel cellulose-based hydrogels with enhanced superabsorbent, mechanical, and antimicrobial properties.
  • To investigate the influence of quaternized cellulose content on hydrogel performance for hygienic applications.

Main Methods:

  • Fabrication of cellulose-based hydrogels through chemical cross-linking of quaternized cellulose (QC) and native cellulose in a NaOH/urea aqueous solution.
  • Characterization of hydrogel properties including swelling ratio, mechanical strength, biocompatibility, and antimicrobial efficacy against Saccharomyces cerevisiae.

Main Results:

  • The prepared hydrogels demonstrated excellent superabsorbent capacity, high mechanical strength, and good biocompatibility.
  • Significant antimicrobial activity against Saccharomyces cerevisiae was observed, attributed to the quaternized cellulose component.
  • Swelling, mechanical, and antibacterial properties were found to be dependent on the concentration of quaternary ammonium groups.

Conclusions:

  • Novel cellulose-based hydrogels incorporating quaternized cellulose offer superior performance compared to conventional materials.
  • These hydrogels exhibit promising potential for use in hygienic applications, particularly disposable diapers, due to their enhanced safety and efficacy.
  • The quaternized cellulose content is a critical factor in tailoring hydrogel properties for specific applications.