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Updated: Mar 28, 2026
Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
Published on: September 20, 2017
Hydrophobic lappaconitine loaded into iota-carrageenan by one step self-assembly
Wenxiu Sun1, Marleny D A Saldaña2, Yujia Zhao2
1College of Food Science and Engineering, Inner Mongolia Agricultural University, Hohhot 010018 China; Department of Agricultural, Food and Nutritional Science (AFNS), University of Alberta, T6G 2P5 Edmonton, AB, Canada; College of life sciences, Northwest Normal University, Lanzhou 730070 China.
Abstract:
New data on the loading of pH-sensitive lappaconitine loaded into iota-carrageenan (LA-ICG) is provided. This LA-ICG ionic biopolymer was prepared by one step self-assembly. The LA-ICG was characterized in terms of the loading capacity, lappaconitine (LA) releasing behavior, pH-sensitivity, and analgesic properties. Iota-carrageenan (ICG) high loading capacity reached up to 26.18% (w/w). Also, the LA, loaded with ICG, was released faster in an acidic environment than that in neutral or alkaline environments. Animal analgesic experiments showed that the LA-ICG of low molecular weight had earlier onset time and longer duration than the LA. These results suggest that the ICG of low molecular weight has great potential to achieve the synergistic effect of LA. In addition, the ICG can be used as a novel natural polymeric carrier for loading a hydrophobic alkaloid.
