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Updated: Mar 28, 2026

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
Immunosurveillance and immunotherapy of tumors by innate immune cells
Alexandre Iannello1, Thornton W Thompson1, Michele Ardolino1
1Department of Molecular and Cell Biology, and Cancer Research Laboratory, 489 Life Sciences Addition, University of California at Berkeley, Berkeley, CA 94720, USA.
Abstract:
Increasing evidence supports a role for innate immune effector cells in tumor surveillance. Natural killer (NK) cells and myeloid cells represent the two main subsets of innate immune cells possessing efficient but quite different tumor suppressive abilities. Here, we describe the germline-encoded NK cell receptors that play a role in suppressing tumor development and describe briefly the cellular pathways leading to the upregulation of their ligands in tumor cells. We also describe mechanisms underlying the elimination of tumor cells by macrophages and a recently characterized mechanism dedicated to sensing cytosolic DNA that is implicated in antitumor immune responses.
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