Related Experiment Video
Updated: Mar 28, 2026
11:35
The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
Published on: June 30, 2014
58.9K
Estimating a Preference-Based Index for an Eight-Dimensional Health State Classification System for Multiple
Elizabeth Goodwin1, Colin Green2, Anne Spencer1
1Health Economics Group, University of Exeter Medical School, University of Exeter, Exeter, UK.
Summary
This study developed the MSIS-8D, a new tool to measure health preferences for multiple sclerosis (MS) patients. This allows for better economic evaluations of MS treatments using quality-adjusted life-years.
Area of Science:
- Health Economics
- Quality of Life Research
- Multiple Sclerosis (MS) Research
Background:
- Condition-specific measures for multiple sclerosis (MS) quality of life are unsuitable for economic evaluations.
- Existing measures lack preference-based values needed for cost-per-quality-adjusted life-year analyses.
Purpose of the Study:
- To estimate a preference-based single index, the Multiple Sclerosis Impact Scale - Eight Dimensions (MSIS-8D).
- To derive the MSIS-8D from the MSIS-29, an existing MS-specific quality of life measure.
Main Methods:
- Elicited preferences for MSIS-8D health states from 1702 UK general population participants using a time trade-off technique via an internet survey.
- Fitted regression models to estimate values for all MSIS-8D health states.
- Validated the MSIS-8D index against MSIS-29 scores and generic preference-based measures in people with MS.
Main Results:
- The time trade-off questions were easily understood by participants.
- Estimated health state values ranged from 0.08 to 0.89, with a best-performing model achieving a mean absolute error of 0.04.
- The MSIS-8D index showed stronger correlation with MSIS-29 scores than generic measures and effectively discriminated between MS subgroups.
Conclusions:
- The MSIS-8D provides a method to estimate health state values from the MSIS-29 for multiple sclerosis.
- This new tool enhances the assessment of health outcomes and quality-adjusted life-year estimation for MS.
- The MSIS-8D supports health technology assessment and decision-making in MS care.
Related Concept Videos
01:17Classification of Illness
9.3K
The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
9.3K
01:26Classification of Systems-I
668
Linearity is a system property characterized by a direct input-output relationship, combining homogeneity and additivity.
Homogeneity dictates that if an input x(t) is multiplied by a constant c, the output y(t) is multiplied by the same constant. Mathematically, this is expressed as:
Homogeneity dictates that if an input x(t) is multiplied by a constant c, the output y(t) is multiplied by the same constant. Mathematically, this is expressed as:
668