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High predicted strain coverage by the multicomponent meningococcal serogroup B vaccine (4CMenB) in Poland

Izabela Waśko1, Eva Hong2, Rosita De Paola3

  • 1National Reference Centre for Bacterial Meningitis (NRCBM), National Medicines Institute, Warsaw, Poland.

Vaccine
|December 22, 2015
PubMed

Insights

The 4CMenB vaccine shows high predicted coverage for invasive meningococcal B disease strains in Poland. This multicomponent vaccine covers over 83% of strains, offering significant protection against serogroup B meningococcal disease.

Area of Science:

  • Microbiology
  • Vaccinology
  • Epidemiology

Background:

  • Neisseria meningitidis serogroup B (MenB) is a leading cause of invasive meningococcal disease (IMD) in Poland and Europe, responsible for over 70% of cases.
  • Effective vaccination strategies are crucial for controlling MenB outbreaks.

Purpose of the Study:

  • To estimate the strain coverage of the multicomponent meningococcal serogroup B vaccine (4CMenB) in Poland.
  • To assess the potential efficacy of 4CMenB against circulating MenB strains.

Main Methods:

  • Analysis of 196 invasive MenB strains isolated in Poland between 2010 and 2011.
  • Utilized the meningococcal antigen typing system (MATS) and molecular characterization (MLST, gene sequencing for porA, fHbp, nhba, nadA).
  • Combined MATS and molecular data for comprehensive coverage assessment.

Main Results:

  • MATS predicted 83.7% coverage of Polish MenB isolates by the 4CMenB vaccine.
  • Individual antigen coverage varied: fHbp (73.0%), NHBA (28.6%), NadA (1.0%), and PorA (10.2%).
  • Molecular analysis identified prevalent clonal complexes (cc32, cc18, cc41/44) with high predicted vaccine coverage (98.5%, 88.6%, 93.5% respectively).

Conclusions:

  • The 4CMenB vaccine is predicted to provide high coverage against invasive MenB strains circulating in Poland.
  • Findings align with European data, suggesting broad applicability of 4CMenB in the region.
  • The study supports the potential of 4CMenB as a key tool in preventing MenB-IMD in Poland.
Keywords:
4CMenB vaccineMATSMeningococcal diseaseVaccine coverage

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