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Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor

Sumangali Kailainathan1, Thomas M Piers2, Jee Hyun Yi3

  • 1Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, Faculty of Health Sciences, University of Bristol, Whitson Street, Bristol BS1 3NY, UK; Learning & Research, School of Clinical Sciences, Faculty of Health Sciences, Southmead Hospital, Bristol BS10 5NB, UK.

Pharmacological Research
|December 22, 2015
PubMed

Keywords:
Binding kineticsChemical compounds studied in this articleGSK3β inhibitor CT-99021 6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl) pyrimidin-2-yl]] amino] ethylamino] pyridine-3-carbonitrile. Cas no. 252917-06-9Long-term depression (LTD)Neurotrophin receptorsPro-brain-derived neurotrophic factor (proBDNF)Val66Met polymorphism

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