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Potential Indications for Tissue Engineering in Temporomandibular Joint Surgery
Jean R Salash1, Reem H Hossameldin2, Alejandro J Almarza3
1Graduate Student, Bioengineering Graduate Program, University of Kansas, Lawrence, KS.
Summary
This study establishes key indications and contraindications for using engineered temporomandibular joint (TMJ) components in reconstructive surgery. It guides tissue engineers in developing targeted TMJ tissue engineering solutions for specific patient needs.
Area of Science:
- Biomedical Engineering
- Musculoskeletal Tissue Engineering
- Regenerative Medicine
Background:
- Musculoskeletal tissue engineering enables the creation of temporomandibular joint (TMJ) components.
- A lack of defined indications hinders the clinical application of TMJ tissue engineering solutions.
Purpose of the Study:
- To establish initial indications and contraindications for using engineered tissues in TMJ reconstruction.
- To guide the development of targeted TMJ tissue engineering technologies.
Main Methods:
- Expert consensus among authors on indications and contraindications.
- Review of existing literature and clinical scenarios.
Main Results:
- Consensus indications include irreparable condylar trauma, developmental/acquired TMJ pathology in immature patients, hyperplasia, and metal hypersensitivity.
- Potential indications for TMJ disc/fossa liner include Wilkes stage III internal derangement; controversial indications include arthritis and failed alloplasts.
- Contraindications include multiple failed surgeries, parafunctional habits, infection, rheumatoid arthritis, and ankylosis.
Conclusions:
- Biomedical engineers should focus on clinical problems needing resolution for TMJ reconstruction.
- Developing technologies requires understanding specific patient needs and tailoring solutions.
- The established indications and contraindications serve as a guide for future TMJ tissue engineering development.
