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Architectonic Mapping of the Human Brain beyond Brodmann
1Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425 Jülich, Germany; C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, 40001 Düsseldorf, Germany; JARA-BRAIN, Jülich-Aachen Research Alliance, 52425 Jülich, Germany.
Neuron
|December 22, 2015
Summary
This study challenges Brodmann's map, proposing a triple-scale concept for brain architecture. New methods reveal more heterogeneous cortical areas than previously understood.
Area of Science:
- Neuroscience
- Brain Mapping
- Cortical Architecture
Background:
- Brodmann pioneered structural brain mapping using cytoarchitecture, functional, and pathological criteria.
- His map defined cortical areas but may oversimplify the brain's complexity.
Purpose of the Study:
- To argue that cortical architecture is more heterogeneous than Brodmann's map suggests.
- To propose a new triple-scale concept for understanding cortical areas.
- To redefine criteria for cortical area definition.
Main Methods:
- Utilizing novel preparations, imaging, and optical methods.
- Applying 2D and 3D quantitative architectonics.
- Employing high-performance computing and big data analysis.
Main Results:
- The proposed triple-scale concept includes modular-like structures and micro/meso-maps.
- New approaches reveal a more complex and heterogeneous cortical organization.
- Traditional mosaic-like segregation of the cerebral cortex is challenged.
Conclusions:
- Cortical architecture exhibits greater heterogeneity than previously recognized.
- A triple-scale concept offers a more nuanced understanding of brain organization.
- Advanced methods are crucial for multi-level brain analysis.
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