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Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies
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Drug the Bug!

Annika Lindskog Jonsson1, Fredrik Bäckhed2

  • 1The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg SE-413 45, Sweden.

Cell
|December 22, 2015
PubMed

Insights

Microbial metabolism contributes to cardiovascular disease. Inhibiting microbial TMA lyases, which produce pro-atherogenic trimethylamines, effectively prevents atherosclerosis in animal models.

Area of Science:

  • Microbiology
  • Cardiovascular Science
  • Metabolomics

Background:

  • Microbial metabolism of dietary components is a known factor in cardiovascular disease (CVD) and atherosclerosis.
  • Specific microbial metabolites, such as trimethylamines, are implicated as pro-atherogenic.

Purpose of the Study:

  • To investigate the role of microbial TMA lyases in the production of trimethylamines.
  • To determine if inhibiting microbial TMA lyases can prevent atherosclerosis in vivo.

Main Methods:

  • Utilized genetic and pharmacological approaches to inhibit microbial TMA lyases.
  • Assessed atherosclerosis development in animal models following TMA lyase inhibition.
  • Measured trimethylamine levels and other relevant biomarkers.

Main Results:

  • Demonstrated that inhibition of microbial TMA lyases significantly reduces trimethylamine production.
  • Showcased a marked prevention of atherosclerosis in vivo upon TMA lyase inhibition.
  • Confirmed the causal link between microbial TMA production and atherosclerosis progression.

Conclusions:

  • Microbial TMA lyases are critical for generating pro-atherogenic trimethylamines from dietary sources.
  • Inhibition of microbial TMA lyases represents a potential therapeutic strategy for preventing atherosclerosis.

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