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High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
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Published on: March 24, 2015

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SnapShot: Interferon Signaling

Kwan T Chow1, Michael Gale1

  • 1Department of Immunology, Center for Innate Immunity and Immune Disease, University of Washington School of Medicine, 750 Republican Street, Seattle, WA 98109, USA.

Cell
|December 22, 2015
PubMed

Interferons (IFNs) are crucial cytokines of antimicrobial, antitumor, and immunomodulatory activity. The three types of IFN (I, II, and III) are classified by their receptor specificity and sequence homology. IFNs are produced and secreted by cells in response to specific stimuli. Here, we review the subsequent IFN signaling events occurring through unique receptors leading to regulation of gene expression for modulation of innate and adaptive immunity. To view this SnapShot, open or download the PDF.

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