Related Experiment Video
Updated: Mar 28, 2026
Using In Vitro Live-cell Imaging to Explore Chemotherapeutics Delivered by Lipid-based Nanoparticles
Published on: November 1, 2017
Enhanced Ehrlich tumor inhibition using DOX-NP and gold nanoparticles loaded liposomes
Mohsen Mahmoud Mady1, Fatima Hasan Al-Shaikh2, Faridah Farhan Al-Farhan2
1Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia / Department of Biophysics, Faculty of Science, Cairo University, Giza, Egypt.
Abstract:
Treatment with doxorubicin (DOX) is a common treatment for different types of cancer. DOX-NP is one of a well established marketed liposomal formulation for DOX. It has advantages over free DOX in reducing the cardiac toxicity and increasing the efficacy. Gold nanoparticles (GNPs), have been widely used in biomedical applications such as medical imaging and biosensors. Mice bearing Ehrlich tumor were injected with saline, free doxorubicin (DOX) in solution, gold nanoparticles loaded liposomes and commercial liposomal encapsulated doxorubicin (DOX-NP). The results showed that GNPs loaded liposomes could enhance the antitumor activity of commercial liposomal formulation (DOX-NP) and displayed significantly decreased systemic toxicity compared with free DOX and commercial liposomal formulation (DOX-NP) at the equivalent dose. So the injection of GNPs and DOX-NP is expected to increase the cell killing and make it a promising approach to cancer treatment.
