Related Experiment Video
Updated: Mar 28, 2026
Preparation of Herbal Medicine: Er-Xian Decoction and Er-Xian-containing Serum for In Vivo and In Vitro Experiments
Published on: May 31, 2017
Exogenetic insulin increased bone mineral densityin middle-aged male patients with type 2 diabetes mellitus
Kaijian Hou1, Chuanjian Lin1, Bangtai Wu1
1Traditional Chinese Medicine Hospital of Shantou, Affiliated Hospital of Traditional Chinese Medicine University of Guangzhou, Guangzhou, China.
Abstract:
We aimed to evaluate the influence of exogenetic insulin on bone mineral density (BMD) in Type 2 Diabetes Mellitus (T2DM). Group A included 120 cases of middle-aged male patients with type 2 diabetes mellitus were administrated exogenetic insulin (40 cases in Group A1: for less than 1 year; 40 cases in Group A2:for 1 to 3 years; 40cases in Group A3: for 3 to 5 years), and another 120 cases (Group B) of middle-aged male patients with type 2 diabetes mellitus were administrated insulin secretagogues. The measurements of BMD of lumbar vertebra (L2-4), collum femoris and total body were conducted with dual-energy X-raya bsorptiometry, followed by the determination of glycosylated hemoglobin, plasma insulin concentration (fasting and postprandial), and fasting C-peptide. Our results revealed that there was no statistical difference of BMD (P&>0.05) between patients in Group A1 or A3andpatients in Group B (B1, B2 or B3), while the BMD in Group A2 increased significantly (P&<0.05). And the fracture risk in Group A3 increased significantly (P&<0.05) compared with Group B (B1, B2 or B3), Taken together, exogenetic insulin significantly increased BMD and fracture risk of middle-aged male patients with type 2 diabetes mellitus.
Related Concept Videos
01:29Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:16Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
01:17Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
01:25Role of Vitamins in Maintaining Bone Health
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...