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Related Concept Videos

Brain Imaging01:14

Brain Imaging

927
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
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Positron Emission Tomography01:29

Positron Emission Tomography

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
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Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
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Related Experiment Video

Updated: Mar 28, 2026

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis
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PET Neurochemical Imaging Modes.

Michael S Placzek1, Wenjun Zhao2, Hsiao-Ying Wey2

  • 1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA; Department of Psychiatry, McLean Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA.

Seminars in Nuclear Medicine
|December 22, 2015
PubMed
Summary

Positron Emission Tomography (PET) is crucial for studying the living human brain

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Radiochemistry

Background:

  • Positron Emission Tomography (PET) has a long history in neuroscience, initially used for brain tumor and metabolism imaging.
  • PET has become a prominent tool for studying neurochemistry in the living human brain over recent decades.
  • Neurochemical imaging with PET has expanded to investigate protein density, drug occupancy, and endogenous neurochemical release.

Purpose of the Study:

  • To provide an introduction to neurochemical PET imaging for interested researchers.
  • To orient readers to three common neurochemical PET imaging modes.
  • To highlight the considerations for quantitative measurements and suggest areas for future expansion.

Main Methods:

  • The article reviews common neurochemical imaging modes using Positron Emission Tomography (PET).
  • It discusses distinct design and analysis considerations critical for quantitative measurements in PET studies.
  • The focus is on providing perspective for those new to the field.

Main Results:

  • PET imaging allows for quantitative measurements of neurochemical processes in the human brain.
  • Understanding specific design and analysis considerations is essential for accurate PET studies.
  • The article identifies the need for further expansion in neurochemical PET imaging techniques.

Conclusions:

  • Neurochemical PET imaging is a powerful tool for neuroscience research.
  • Despite complexities, PET offers valuable insights into brain chemistry.
  • Further development is needed to broaden the accessibility and applications of neurochemical PET imaging.