Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

856
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
856
The Influence of Cognition on Affect01:29

The Influence of Cognition on Affect

291
Cognition plays a pivotal role in shaping emotional experiences, as demonstrated by Schachter and Singer’s two-factor theory of emotion. According to this model, emotion arises from a combination of physiological arousal and cognitive interpretation. The body’s physiological response to stimuli is ambiguous and only gains emotional significance through cognitive labeling. For instance, an increased heart rate and adrenaline surge while standing near an attractive person may be...
291
Depression: Overview01:18

Depression: Overview

1.2K
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
1.2K
The Influence of Affect on Cognition01:29

The Influence of Affect on Cognition

384
Positive affect significantly influences cognitive processes, including evaluation, memory, creativity, and social judgments. Compared to negative affect, positive emotional states promote more favorable interpretations of stimuli, cognitive flexibility, and heuristic processing. These effects highlight emotions' powerful role in shaping how individuals perceive, remember, and interact with the world.Influence on Evaluation and AttributionWhen individuals experience positive affect, they are...
384
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

1.1K
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
1.1K
Bipolar Disorder01:30

Bipolar Disorder

1.4K
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of immunomodulators in severe mental disorders: future perspectives.

Current opinion in psychiatry·2024
Same author

Anhedonia is associated with a specific depression profile and poor antidepressant response.

The international journal of neuropsychopharmacology·2024
Same author

Hypomanic symptoms in major depressive disorder: Prognostic impact and treatment issues.

Journal of affective disorders·2024
Same author

Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial - CORRIGENDUM.

The British journal of psychiatry : the journal of mental science·2024
Same author

Projections of anxiety disorder prevalence during and beyond the COVID-19 pandemic in Germany using the illness-death model.

BJPsych open·2024
Same author

Epigenome-Wide DNA Methylation in Unipolar Depression: Predictive Biomarker of Antidepressant Treatment Response?

The international journal of neuropsychopharmacology·2024
Same journal

Biofluid Biomarkers of Cognitive Functioning in Bipolar Disorder: A Systematic Review by the Targeting Cognition and Older-Age Bipolar Disorder ISBD Task Forces.

Bipolar disorders·2026
Same journal

Enhancing Affective Cognitive Control in Bipolar Disorder Using Transcranial Alternating Current Stimulation: A Double-Blind, Randomized, Sham-Controlled Clinical Trial and Proof of Concept Study.

Bipolar disorders·2026
Same journal

Psychotropic Prescribing Patterns Among Bipolar-I Patients Prior to Established Bipolar-I Disorder Diagnosis.

Bipolar disorders·2026
Same journal

Speech and Language Markers of Bipolar Disorder: Challenges and Opportunities.

Bipolar disorders·2026
Same journal

Can We Improve the Prediction of Early Onset Mania and Hypomania in the Community?

Bipolar disorders·2026
Same journal

How Do Parents With Bipolar Disorder Perceive the Risk to the Next Generation? Results From a Qualitative Study.

Bipolar disorders·2026
See all related articles

Related Experiment Video

Updated: Mar 28, 2026

Animal Models of Depression - Chronic Despair Model CDM
05:47

Animal Models of Depression - Chronic Despair Model CDM

Published on: September 23, 2021

8.4K

Mood disorders: neurocognitive models.

Gin S Malhi1,2,3, Yulisha Byrow1,2,3, Kristina Fritz1,2,3

  • 1Academic Department of Psychiatry, Kolling Institute, Northern Sydney Local Health District, St Leonards, NSW 2065, Australia.

Bipolar Disorders
|December 22, 2015
PubMed
Summary
This summary is machine-generated.

Integrating neurocognitive models enhances understanding of mood disorders. This approach synthesizes neural mechanisms and cognitive functions for improved diagnosis and treatment strategies in psychiatry.

Keywords:
bipolar disordercognitionemotionmajor depressive disordermood disordersneuralneurocognitionpathophysiology

More Related Videos

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

1.3K
Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

1.7K

Related Experiment Videos

Last Updated: Mar 28, 2026

Animal Models of Depression - Chronic Despair Model CDM
05:47

Animal Models of Depression - Chronic Despair Model CDM

Published on: September 23, 2021

8.4K
Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

1.3K
Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

1.7K

Area of Science:

  • Cognitive Neuroscience
  • Psychiatry
  • Psychology

Background:

  • Neurocognitive models conceptualize mood disorder pathophysiology via dysfunctional neural mechanisms.
  • Existing models offer theoretical insights but lack clinical integration.
  • Cognitive neuroscience offers a novel perspective for mood disorder research.

Purpose of the Study:

  • To develop an integrative neurocognitive approach for mood disorders.
  • To create a template for future research and clinical application.
  • To establish a clinically meaningful framework for mood disorder investigation, diagnosis, and treatment.

Main Methods:

  • A selective literature search was conducted.
  • Databases used included PubMed and PsychINFO.
  • Prominent neurobiological and neurocognitive models of mood disorders were identified.

Main Results:

  • Most models identify similar neural networks and neuropsychological processes.
  • Models differ in specific functions attributed to neural processes and their interactions.
  • Integration of cognitive biases, reward processing, rumination, and mood stability enhances understanding of mood disorders.

Conclusions:

  • Integrating cognitive functions with neural functioning in neurocognitive models is crucial.
  • This integration can create a research framework for clinical translation.
  • The proposed framework aids in the diagnosis and treatment of mood disorders.