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Updated: Mar 28, 2026
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An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
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Plan Beta for tuberculosis: it's time to think seriously about poorly ventilated congregate settings
T A Yates1, F Tanser2, I Abubakar3
1Centre for Infectious Disease Epidemiology, Research Department of Infection and Population Health, University College London, London, UK; Wellcome Trust Africa Centre for Population Health, University of KwaZulu-Natal, Mtubatuba, South Africa.
Summary
Tuberculosis (TB) control is slow globally. Evidence suggests most Mycobacterium tuberculosis transmission occurs indoors, indicating environmental modifications could significantly impact TB control efforts.
Area of Science:
- Epidemiology
- Molecular Epidemiology
- Mathematical Modeling
Background:
- Global tuberculosis (TB) incidence decline rates are suboptimal.
- Current TB control strategies, like DOTS, show limited impact.
- Most Mycobacterium tuberculosis transmission likely occurs in indoor congregate settings.
Purpose of the Study:
- To review evidence on TB transmission in indoor settings.
- To propose environmental modifications as a TB control strategy.
- To suggest a research agenda for TB environmental interventions.
Main Methods:
- Review of basic epidemiological data.
- Analysis of molecular epidemiological findings.
- Evaluation of mathematical modeling studies.
Main Results:
- Consistent evidence points to indoor congregate settings as primary TB transmission sites.
- Environmental modifications in these settings could substantially reduce TB transmission.
- Existing technologies can be implemented without reliance on scarce healthcare workers.
Conclusions:
- Targeting indoor environments offers a promising, feasible strategy for TB control.
- Further research is needed to guide effective environmental intervention implementation.
- Non-healthcare worker-dependent interventions are crucial for high-burden TB settings.
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