Related Experiment Video

Updated: Mar 28, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.9K

Systemic Inflammatory Markers Are Closely Associated with Atherogenic Lipoprotein Subfractions in Patients Undergoing

Yan Zhang1, Sha Li1, Rui-Xia Xu1

  • 1Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, BeiLiShi Road 167, Beijing 100037, China.

Mediators of Inflammation
|December 22, 2015
PubMed

Insights

Systemic inflammatory markers correlate with atherogenic lipoprotein subfractions, including small LDL cholesterol and LDL score, and inversely with large HDL cholesterol. This highlights their role in cardiovascular risk.

Area of Science:

  • Cardiovascular Science
  • Lipid Metabolism
  • Inflammation Biology

Background:

  • Atherosclerosis is a leading cause of cardiovascular disease.
  • Inflammation and lipoprotein metabolism are key contributors to atherogenesis.
  • Understanding the interplay between inflammatory markers and specific lipoprotein subfractions is crucial for risk assessment.

Purpose of the Study:

  • To investigate the relationship between systemic inflammatory markers and atherogenic lipoprotein subfractions.
  • To determine if inflammatory markers correlate with specific low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particle characteristics.

Main Methods:

  • Studied 520 subjects not on lipid-lowering therapy.
  • Measured inflammatory markers: white blood cell (WBC) count, high-sensitivity C-reactive protein (hs-CRP), fibrinogen, erythrocyte sedimentation rate (ESR), and D-dimer.
  • Utilized the Lipoprint System for LDL and HDL subfraction analysis.

Main Results:

  • Inflammatory markers (WBC, hs-CRP, fibrinogen, ESR) positively correlated with non-HDL cholesterol, remnant cholesterol, very low-density lipoprotein cholesterol, small LDL cholesterol, and LDL score.
  • A negative association was found between inflammatory markers and mean LDL particle size and large HDL cholesterol.
  • These associations were more pronounced in patients with coronary artery disease (CAD).

Conclusions:

  • Systemic inflammation is linked to atherogenic lipoprotein profiles.
  • Positive correlations exist with small LDL cholesterol and LDL score.
  • Negative correlations observed with mean LDL particle size and large HDL cholesterol, suggesting increased cardiovascular risk.
Abstract

More Related Videos

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.9K
A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

13.8K

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
742
Inflammation01:38

Inflammation

Overview
64.2K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
2.0K
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
421
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
1.1K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
955