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Modeling the tumor microenvironment using chitosan-alginate scaffolds to control the stem-like state of glioblastoma
Forrest M Kievit1, Kui Wang, Ariane E Erickson
1Department of Neurological Surgery, University of Washington, Seattle, WA 98195, USA. mzhang@uw.edu rge@uw.edu.
Biomaterials Science
|December 22, 2015
Abstract:
Better prediction of in vivo drug efficacy using in vitro models should greatly improve in vivo success. Here we utilize 3D highly porous chitosan-alginate complex scaffolds to probe how various components of the glioblastoma microenvironment including extracellular matrix and stromal cells affect tumor cell stem-like state.
