Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

[Sustained-release Opioids: Morphine, Oxycodone and Tapentadol].

Yoshika Takahashi, Masako Iseki

Masui. the Japanese Journal of Anesthesiology

|December 23, 2015

Summary

This review details sustained-release opioid formulations, including morphine, oxycodone, and tapentadol, used for managing cancer pain in Japan. It focuses on their pharmacokinetic properties for effective pain relief.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Feasibility of a Monthly Morphine Milligram Equivalent Metric for Opioid Surveillance Using the National Claims Database of Japan: A Repeated Cross-Sectional Study in a Low-Consumption Setting.

Therapeutic innovation & regulatory science·2026

Same author

Current Strategies and Future Perspectives in the Management of Opioid-Induced Constipation: A Review of International and Japanese Guidelines.

Neurogastroenterology and motility·2026

Same author

RE: Response to the readers' comments on our guidelines: Executive summary of the guidelines for prescribing opioid analgesics for chronic non-cancer pain (third edition) by the Japan Society of Pain Clinicians.

Journal of anesthesia·2026

Same author

Addiction-related problems in Japan: A regional perspective.

Addiction (Abingdon, England)·2025

Same author

Sleep Quality in Chronic Pain Patients With and Without Strong Opioid Use: An Observational Study Using a Wearable Device.

Neuropsychopharmacology reports·2025

Same author

Executive summary of the guideline for prescribing opioid analgesics for chronic non-cancer pain (third edition) by the Japan Society of Pain Clinicians.

Journal of anesthesia·2025

Area of Science:

Pharmacology
Pain Management
Oncology

Background:

Opioid analgesics are essential for moderate to severe pain, particularly in cancer patients.
Sustained-release (SR) opioids provide continuous pain control, while immediate-release formulations manage breakthrough pain.
SR opioids stabilize blood concentrations but require time to achieve therapeutic effects.

Purpose of the Study:

To review the pharmacokinetic properties of available oral sustained-release opioid analgesics in Japan.
To discuss specific SR morphine, oxycodone, and tapentadol formulations used in cancer pain management.

Main Methods:

Literature review of pharmacokinetic data for oral SR opioid analgesics.
Focus on formulations available in Japan: MS Contin, Morphes, Kadian, P guard, Pacif (SR morphine), Oxycontin (SR oxycodone), and Tapenta (SR tapentadol).

Main Results:

The article provides an overview of the pharmacokinetic characteristics of several SR opioid drugs.
It highlights the availability of once-daily and twice-daily SR morphine formulations in Japan.
Specific SR oxycodone and tapentadol products are also discussed.

Conclusions:

Understanding the pharmacokinetic profiles of SR opioids is crucial for optimizing cancer pain management.
The availability of diverse SR formulations allows for tailored pain relief strategies.
Further discussion on these properties can aid clinicians in Japan.

Related Experiment Videos