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Probiotics01:22

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Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
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Allergic Reactions: Anaphylaxis01:30

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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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Humanized Mediator Release Assay as a Read-Out for Allergen Potency
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Probiotics for allergy prevention.

C E West1

  • 11 Department of Clinical Sciences, Unit for Pediatrics, Umeå University, 901 85 Umeå, Sweden.

Beneficial Microbes
|December 23, 2015
PubMed
Summary
This summary is machine-generated.

Probiotics show moderate benefit for eczema prevention, especially multi-strain formulas in high-risk infants. More research is needed for other allergies and long-term effects.

Keywords:
asthmachildreneczemamicrobiotaprobiotic

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Area of Science:

  • Immunology
  • Microbiology
  • Pediatrics

Background:

  • Probiotics are evaluated for allergy prevention in infants.
  • Studies use various probiotic strains and administration timings.

Purpose of the Study:

  • To review primary prevention studies of probiotics for allergy.
  • To discuss current strategies and evidence.

Main Methods:

  • Review of randomized controlled trials and meta-analyses.
  • Analysis of probiotic strains, dosages, and timing.

Main Results:

  • Moderate benefit for eczema prevention, particularly with multi-strain probiotics in high-risk infants.
  • No proven effect for other allergic manifestations.
  • Limited long-term data for asthma and allergic rhinitis.

Conclusions:

  • Current evidence suggests a moderate benefit for eczema prevention.
  • Expert bodies do not generally recommend probiotics for allergy prevention.
  • Further standardized, adequately powered trials are needed.