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Compact Quantum Dots for Single-molecule Imaging

Compact Quantum Dots for Single-molecule Imaging

Published on: October 9, 2012

Cell Nucleus-Targeting Zwitterionic Carbon Dots.

Yun Kyung Jung¹, Eeseul Shin¹, Byeong-Su Kim^1,2

¹Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), UNIST-gil 50, Ulsan 689-798, Republic of Korea.

Scientific Reports

|December 23, 2015

Summary

This summary is machine-generated.

Researchers developed nucleus-targeting zwitterionic carbon dots (CDs) for enhanced anticancer drug delivery and optical monitoring. This novel nanoparticle system improves drug efficacy by targeting the nucleus and enabling precise tracking.

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Spatiotemporally Controlled Nuclear Translocation of Guests in Living Cells Using Caged Molecular Glues as Photoactivatable Tags

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Published on: January 17, 2019

Area of Science:

Nanotechnology
Biomedical Engineering
Materials Science

Background:

Developing targeted drug delivery systems is crucial for improving cancer therapy efficacy.
Carbon dots (CDs) offer potential as drug carriers due to their unique optical and physicochemical properties.
Achieving efficient nuclear delivery of therapeutic agents remains a significant challenge.

Purpose of the Study:

To develop an innovative nucleus-targeting zwitterionic carbon dot (CD) vehicle for enhanced anticancer drug delivery.
To utilize the multicolor fluorescence of CDs for accurate optical monitoring of drug translocation.
To evaluate the in vitro and in vivo antitumor efficacy of the CD-based drug delivery system.

Main Methods:

One-step synthesis of zwitterionic carbon dots using beta-alanine as a passivating ligand.
Non-covalent grafting of doxorubicin onto the synthesized carbon dots.
In vitro cellular uptake and nuclear translocation studies.
In vivo tumor accumulation and antitumor efficacy assessments.

Main Results:

Zwitterionic CDs demonstrated efficient cytoplasmic uptake and subsequent nuclear translocation.
Multicolor fluorescence of CDs enabled accurate optical tracking.
The doxorubicin-loaded CD system exhibited superior antitumor efficacy in vitro and in vivo.
Significant tumor growth inhibition was observed due to enhanced nuclear delivery and tumor accumulation.

Conclusions:

A novel nucleus-targeting zwitterionic carbon dot vehicle was successfully developed.
The zwitterionic CDs facilitate enhanced nuclear drug delivery and provide a platform for optical monitoring.
This multifunctional nanoparticle system shows significant potential for improving anticancer therapy and tumor visualization.