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Ménétrier's Disease: Its Mimickers and Pathogenesis.

Won Jae Huh1, Robert J Coffey2, Mary Kay Washington1

  • 1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.

Journal of Pathology and Translational Medicine
|December 23, 2015
PubMed
Summary
This summary is machine-generated.

Ménétrier's disease, a rare hypertrophic gastropathy, can be misdiagnosed due to histological similarities with other conditions. Epidermal growth factor receptor (EGFR) signaling is implicated in its pathogenesis.

Keywords:
Gastric polypMénétrier’s diseaseTransforming growth factor alpha

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Area of Science:

  • Gastroenterology
  • Pathology
  • Molecular Biology

Background:

  • Ménétrier's disease is a rare protein-losing hypertrophic gastropathy.
  • Histological features can lead to misdiagnosis, mimicking other hypertrophic gastropathies.
  • The exact pathogenesis remains unclear, but growth factor signaling is suspected.

Purpose of the Study:

  • To review conditions that mimic Ménétrier's disease.
  • To elucidate the role of epidermal growth factor receptor (EGFR) signaling in Ménétrier's disease pathogenesis.

Main Methods:

  • Literature review focusing on diagnostic challenges and molecular mechanisms.
  • Analysis of existing studies on hypertrophic gastropathy and EGFR signaling pathways.

Main Results:

  • Differential diagnosis of hypertrophic gastropathy is crucial.
  • Transforming growth factor alpha, an EGFR ligand, is a key factor in disease development.

Conclusions:

  • Accurate diagnosis requires careful histological evaluation and consideration of clinical presentation.
  • Targeting EGFR signaling pathways may offer future therapeutic strategies for Ménétrier's disease.