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A Meta-Analysis of the Association between Polymorphisms in MicroRNAs and Risk of Ischemic Stroke

Yan Xiao1,2, Mei-Hua Bao3, Huai-Qing Luo4

  • 1Department of Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha 410219, China. y_xiao@sscta.cn.

Genes
|December 23, 2015
PubMed

Insights

MicroRNA-149 (rs2292832) genetic variations, specifically the TT genotype and T allele, are linked to reduced ischemic stroke risk. Other microRNAs showed no consistent association, though miR-146a warrants further investigation in larger studies.

Area of Science:

  • Genetics
  • Cardiovascular Disease Epidemiology
  • Molecular Biology

Background:

  • Ischemic stroke (IS) is a leading cause of death and disability globally.
  • Genetic polymorphisms in microRNAs (miRNAs) have been implicated in IS risk, but findings are often inconsistent.
  • miR-146a (rs2910164), miR-149 (rs2292832), miR-196a2 (rs11614913), and miR-499 (rs3746444) are among those studied.

Purpose of the Study:

  • To conduct a meta-analysis to precisely estimate the association between four specific miRNA polymorphisms and the risk of ischemic stroke.
  • To clarify inconsistent previous findings regarding the role of these miRNA genetic variations in IS susceptibility.

Main Methods:

  • A systematic literature search was performed across major databases (PubMed, Embase, Cochrane, CNKI, CBM).
  • A meta-analysis was conducted on five selected studies, comprising 2230 IS cases and 2229 controls.
  • Statistical models (homozygous, allelic) were used to assess the association between miRNA genotypes/alleles and IS risk.

Main Results:

  • The TT genotype and T allele of miR-149 (rs2292832) were significantly associated with a lower risk of IS (OR=0.70 and OR=0.86, respectively).
  • No significant associations were found for miR-146a (rs2910164), miR-196a2 (rs11614913), or miR-499 (rs3746444) with IS risk in the overall analysis.
  • Subgroup analysis by sample size revealed a potential protective effect of the CC genotype and C allele of miR-146a (rs2910164) in large sample size groups.

Conclusions:

  • miR-149 (rs2292832) polymorphism may serve as a potential predictor for ischemic stroke risk.
  • miR-146a, miR-196a2, and miR-499 polymorphisms, based on current evidence, are not reliable indicators of IS susceptibility.
  • Further research, particularly larger sample size studies for miR-146a, is needed to confirm these findings.
Keywords:
ischemic strokemeta-analysismiR-146amiR-149miR-196a2miR-499polymorphism

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