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Coordinated Molecular Cross-Talk between Staphylococcus aureus, Endothelial Cells and Platelets in Bloodstream

Carolina D Garciarena1, Tony M McHale2, Rebecca L Watkin3

  • 1Cardiovascular Infection Research Group, School of Pharmacy & Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland. carolinagarciarena@rcsi.ie.

Pathogens (Basel, Switzerland)
|December 23, 2015
PubMed

Insights

Staphylococcus aureus bloodstream infections disrupt cardiovascular function by interacting with endothelial cells and platelets. This pathogen exploits cell wall proteins to cause serious complications, including organ failure.

Area of Science:

  • Cardiovascular Science
  • Infectious Disease
  • Microbiology

Background:

  • Staphylococcus aureus is an opportunistic pathogen that can cause severe bloodstream infections.
  • The cardiovascular system, including endothelial cells and platelets, is a primary target for S. aureus.
  • S. aureus utilizes surface cell wall proteins to interact with host components, facilitating infection.

Purpose of the Study:

  • To review the mechanisms by which Staphylococcus aureus interacts with endothelial cells and platelets.
  • To elucidate how these interactions lead to cardiovascular dysregulation during bloodstream infections.

Main Methods:

  • This review synthesizes existing research on S. aureus interactions with cardiovascular components.
  • Literature analysis focusing on molecular mechanisms of pathogen-host cell engagement.

Main Results:

  • Staphylococcus aureus employs surface proteins to bind to endothelial cells and platelets.
  • These interactions trigger the activation and functional dysregulation of endothelial cells and platelets.
  • Such dysregulation contributes to the pathogenesis of S. aureus bloodstream infections.

Conclusions:

  • Staphylococcus aureus establishes critical interactions with endothelial cells and platelets.
  • These interactions are key to S. aureus pathogenesis in the cardiovascular system.
  • Understanding these interactions is vital for developing strategies against S. aureus bloodstream infections.
Keywords:
Staphylococcus aureusendothelial cellsinfective endocarditisplateletssepsis

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