Related Experiment Video
Updated: Mar 28, 2026

05:00
Rapid Characterization of Genetic Parts with Cell-Free Systems
Published on: August 30, 2021
2.3K
US Competitiveness in Synthetic Biology
1Gigi Kwik Gronvall, PhD, is a Senior Associate, UPMC Center for Health Security , Baltimore, Maryland.
Health Security
|December 23, 2015
Summary
Synthetic biology offers significant economic and national defense benefits. The US must invest in R&D and adapt regulations to maintain leadership in this rapidly advancing field.
Area of Science:
- Synthetic biology engineering
- Biotechnology innovation
Background:
- Synthetic biology (SynBio) is a rapidly advancing field with significant economic implications.
- The US currently leads in SynBio R&D, but global investments pose a challenge to this position.
- SynBio applications span economic growth, national defense, and global governance.
Purpose of the Study:
- To outline strategies for the US to maintain its leadership in synthetic biology.
- To address challenges including global competition and public perception of genetically modified organisms (GMOs).
- To ensure a robust regulatory framework for SynBio products and international cooperation.
Main Methods:
- Analysis of the current synthetic biology landscape and R&D investments.
- Review of potential economic and national security applications of SynBio.
- Examination of regulatory approaches and international agreements impacting SynBio.
Main Results:
- Sustained US leadership requires proactive government strategies beyond general S&T investment.
- Addressing anti-GMO sentiments and legislation is crucial for SynBio development.
- Maintaining a product-based regulatory approach while updating frameworks is essential.
Conclusions:
- The US must act to remain competitive in synthetic biology R&D and application.
- Policy adjustments are needed to counter anti-GMO sentiments and ensure regulatory clarity.
- International engagement is vital for governing SynBio and realizing its benefits.
Related Concept Videos
Synthetic Biology
5.8K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
Golden rice
Golden rice is a genetically modified...
5.8K
Production of Biopesticides
60
Biopesticides offer a sustainable alternative to chemical pesticides, utilizing microbial agents to control agricultural pests. Bacillus thuringiensis (Bt) is a widely employed bacterium known for its potent insecticidal activity. Bt biopesticides are favored for their specificity to insect pests, minimal environmental impact, and natural degradability.Mechanism of Bt Toxin Action Bt produces insecticidal crystal (Cry) proteins during its sporulation phase. These proteins form parasporal...
60
Bioreactor Controls-III
51
Strain improvement is a foundational strategy in industrial microbiology aimed at maximizing microbial productivity, particularly because natural isolates typically yield commercially valuable products in very low concentrations. Although optimizing the culture medium and environmental conditions can improve yields, these adjustments are inherently limited by the organism’s genetic potential. As a result, the focus shifts toward genetic modifications to enhance biosynthetic capacity. The...
51
Upstream Processing
73
Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...
73
Production of Pharmaceuticals
51
Industrial insulin production uses genetically engineered E. coli expressing a proinsulin gene controlled by a tryptophan promoter and containing a methionine linker for later cleavage. The cells also carry ampicillin resistance for selective growth. Seed cultures are stored at −80 °C and production begins by thawing a small amount to inoculate starter cultures, which are progressively scaled to a 50,000-L bioreactor. In the bioreactor, E. coli grow in nutrient-rich media under...
51
The Central Dogma
35.3K
The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
35.3K

