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[Aspirin. Pseudo-allergic reactions].

M Díaz Isaacs

    Revista Medica De Panama
    |May 1, 1989
    PubMed
    Summary

    Aspirin allergy and intolerance affect nearly 10% of allergy patients, often presenting with angioedema and urticaria. Many patients exhibit a history of atopy and cross-reactivity to other medications.

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    Area of Science:

    • Clinical immunology
    • Pharmacology
    • Epidemiology

    Context:

    • Aspirin and non-steroidal anti-inflammatory drug (NSAID) sensitivity are common clinical challenges.
    • Understanding the prevalence and characteristics of aspirin reactions is crucial for patient management.

    Purpose:

    • To analyze the clinical records of patients with suspected aspirin allergy or intolerance.
    • To determine the prevalence, symptoms, associated conditions, and cross-reactivity patterns in these patients.

    Summary:

    • Reviewed 2000 patient records, identifying 197 (9.7%) with aspirin allergy/intolerance (41 acute, 153 intolerance).
    • Common symptoms included angioedema and urticaria. A significant proportion had a history of atopy, allergic rhinitis, or asthma.
    • Pseudoallergic reactions to aspirin/NSAIDs were frequent (53-89%), with cross-reactivity noted for pyrazolones, penicillin, and acetaminophen.

    Impact:

    • Highlights the high prevalence of aspirin sensitivity in allergy patients.
    • Emphasizes the importance of identifying atopy and other drug sensitivities in patients with aspirin reactions.
    • Informs clinical practice regarding patient education on cross-reactive substances.

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