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Targeted therapy for advanced gastric cancer: A review of current status and future prospects

Ozkan Kanat1, Bert O'Neil1, Safi Shahda1

  • 1Ozkan Kanat, Department of Medical Oncology, Uludag University faculty of Medicine, 16059 Bursa, Turkey.

World Journal of Gastrointestinal Oncology
|December 23, 2015
PubMed

Insights

Advanced gastric cancer (GC) treatment is improving with targeted drug therapies. Agents like trastuzumab and ramucirumab offer new hope for patients with advanced disease, changing standard treatment protocols.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Gastric cancer (GC) predominantly presents at advanced stages in Western populations.
  • Current combination chemotherapy offers limited survival benefits for advanced GC.
  • Recent advances reveal key molecular pathways driving gastric carcinogenesis.

Purpose of the Study:

  • To review the clinical status of targeted drug therapies for gastric cancer management.
  • To highlight novel therapeutic agents impacting GC treatment paradigms.

Main Methods:

  • Literature review of clinical trials and studies on targeted therapies in GC.
  • Analysis of molecular signaling pathways implicated in gastric cancer development.
  • Evaluation of the efficacy and impact of specific targeted agents.

Main Results:

  • Targeted agents like trastuzumab and ramucirumab have demonstrated significant clinical efficacy.
  • These targeted therapies are altering the standard treatment protocols for advanced GC.
  • Increased understanding of molecular pathways facilitates the development of new targeted drugs.

Conclusions:

  • Targeted drug therapy represents a significant advancement in managing advanced gastric cancer.
  • Personalized medicine approaches utilizing targeted agents are becoming crucial in GC treatment.
  • Continued research into molecular pathways will likely yield further therapeutic innovations for GC.
Keywords:
AngiogenesisEpidermal growth factorGastric cancerTargeted therapyTreatment

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