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Association between allergic diseases and risks of HSP and HSP nephritis: a population-based study

An-Chyi Chen1,2, Cheng-Li Lin3,4, Te-Chun Shen2,5

  • 1Department of Pediatric Medicine, Children's Hospital of China Medical University Hospital, Taichung, Taiwan.

Pediatric Research
|December 23, 2015
PubMed

Insights

Children with allergies face a higher risk of developing Henoch-Schönlein purpura (HSP). However, having allergies does not increase the risk of developing HSP nephritis in children.

Area of Science:

  • Pediatric Allergy and Immunology
  • Rheumatology
  • Nephrology

Background:

  • Allergic inflammation mediators are implicated in Henoch-Schönlein purpura (HSP).
  • The link between childhood allergic diseases and subsequent HSP risk, including HSP nephritis, is not well-established.

Purpose of the Study:

  • To investigate the association between pre-existing allergic diseases in children and their subsequent risk of developing HSP.
  • To determine if allergic diseases influence the risk of HSP nephritis.

Main Methods:

  • A case-control study involving 2,240 children diagnosed with HSP and 8,960 matched controls.
  • Analysis of odds ratios (ORs) to assess the association between allergic diseases and HSP risk.
  • Examination of HSP nephritis incidence in relation to allergic disease history.

Main Results:

  • Children with allergic diseases exhibited an increased subsequent risk of HSP, with adjusted ORs ranging from 1.33 for allergic conjunctivitis to 1.68 for asthma.
  • The risk of HSP was significantly higher (aOR = 2.03) in children with at least two allergic conditions.
  • Children with HSP nephritis were more likely to have a history of allergic disease (45.8%).

Conclusions:

  • Atopic children have a greater subsequent risk of developing HSP.
  • The presence of allergic diseases in children does not appear to increase the risk of developing HSP nephritis.
Abstract

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