Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Observational Studies01:11

Observational Studies

11.4K
Observational studies are a type of analytical study where researchers observe events without any interventions. In other words, the researcher does not influence the response variable or the experiment's outcome.
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
11.4K
Data Collection by Observations01:08

Data Collection by Observations

15.6K
Data collection refers to a systematic way of obtaining, observing, measuring, and analyzing accurate information. Observational studies are one of the most widely used methods of data collection. It involves collecting data by observing the behavior and physical characteristics of a sample without making any modifications to the sample.
An astronomer viewing the motion and brightness of stars in the sky and recording the data is an example of observational data collection. A botanist recording...
15.6K
Introduction to Epidemiology01:26

Introduction to Epidemiology

2.5K
Epidemiology, known as the cornerstone of public health, involves studying the distribution and determinants of health-related events in defined populations and applying these insights to control health issues. This is essential for understanding how diseases spread, identifying populations at greater risk, and implementing measures to control or prevent outbreaks. Epidemiology addresses not only infectious diseases but also non-communicable conditions like cancer and cardiovascular disease,...
2.5K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

529
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
529
Study Designs in Epidemiology01:20

Study Designs in Epidemiology

1.5K
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
1.5K
Purpose of Health Records II01:19

Purpose of Health Records II

1.5K
Health records serve various essential purposes in the healthcare system. Here are some key purposes:
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effectiveness of recombinant human follicle-stimulating hormone (r-hFSH): recombinant human luteinizing hormone versus r-hFSH alone in assisted reproductive technology treatment cycles among women aged 35-40 years: A German database study.

Best practice & research. Clinical obstetrics & gynaecology·2023
Same author

Comparative effectiveness of gonadotropins used for ovarian stimulation during assisted reproductive technologies (ART) in France: A real-world observational study from the French nationwide claims database (SNDS).

Best practice & research. Clinical obstetrics & gynaecology·2023
Same author

Rare metabolic disease mimicking COL4A1/COL4A2 fetal brain phenotype.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2022
Same author

[Contribution of the pre-operative Mri-coloscan couple in the surgical planning of deep digestive pelvic endometriosis].

Gynecologie, obstetrique, fertilite & senologie·2021
Same author

Spreading violaceous neck plaques in a fatigued man.

Clinical and experimental dermatology·2021
Same author

Measuring the quality of cancer care in the Barwon South Western region, Victoria, Australia.

International journal for quality in health care : journal of the International Society for Quality in Health Care·2020
Same journal

Symposium Report: Stakeholders' Perspectives on Phase 1 Trials in Japanese Prior to Multi-Regional Clinical Trials and Future Pathways.

Clinical pharmacology and therapeutics·2026
Same journal

Resolving CYP2D6 Structural Complexity with Long-Read Sequencing: Implications for Tamoxifen Precision Dosing in Thai Breast Cancer Patients.

Clinical pharmacology and therapeutics·2026
Same journal

Identification of a Functional CYP2C8 Variant Allele that Alters Splicing, Reduces Protein Expression, and Increases Drug Exposure.

Clinical pharmacology and therapeutics·2026
Same journal

Risk of Hyperkalemia in Patients with Heart Failure Treated with Spironolactone in Combination with Sacubitril/Valsartan vs. Renin-Angiotensin System Inhibitors.

Clinical pharmacology and therapeutics·2026
Same journal

Composite Endpoints in Contemporary Cardiovascular Trials: Trends in Phase 3 Trials and Key Issues in Regulatory Review.

Clinical pharmacology and therapeutics·2026
Same journal

Patient-Specific Determinants of Response to BCMA- and GPRC5D-Targeted CAR T-Cell Therapy in Multiple Myeloma: A QSP Analysis of Clinical Trial and Real-World Data.

Clinical pharmacology and therapeutics·2026
See all related articles

Related Experiment Video

Updated: Mar 28, 2026

Databases to Efficiently Manage Medium Sized, Low Velocity, Multidimensional Data in Tissue Engineering
09:43

Databases to Efficiently Manage Medium Sized, Low Velocity, Multidimensional Data in Tissue Engineering

Published on: November 22, 2019

6.9K

Transparency and Reproducibility of Observational Cohort Studies Using Large Healthcare Databases.

S V Wang1, P Verpillat2, J A Rassen3

  • 1Division of Pharmacoepidemiology and Pharmacoeconomics, Harvard Medical/Brigham & Women's Hospital, Boston, Massachusetts, USA.

Clinical Pharmacology and Therapeutics
|December 23, 2015
PubMed
Summary
This summary is machine-generated.

Reproducibility of pharmacoepidemiologic studies using healthcare databases is high when studies are well-reported. This research highlights the need for complete reporting in transparent and reproducible epidemiologic research.

More Related Videos

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data
11:21

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data

Published on: July 27, 2018

9.0K
TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients
09:00

TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients

Published on: April 13, 2021

5.5K

Related Experiment Videos

Last Updated: Mar 28, 2026

Databases to Efficiently Manage Medium Sized, Low Velocity, Multidimensional Data in Tissue Engineering
09:43

Databases to Efficiently Manage Medium Sized, Low Velocity, Multidimensional Data in Tissue Engineering

Published on: November 22, 2019

6.9K
Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data
11:21

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data

Published on: July 27, 2018

9.0K
TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients
09:00

TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients

Published on: April 13, 2021

5.5K

Area of Science:

  • Epidemiology
  • Health Informatics
  • Pharmacovigilance

Background:

  • Growing concerns regarding transparency and reproducibility in epidemiologic studies utilizing longitudinal healthcare databases.
  • Need for validation of published findings through independent reproduction.

Purpose of the Study:

  • To assess the reproducibility of published pharmacoepidemiologic studies conducted using commercially available healthcare databases.
  • To identify factors influencing the successful reproduction of study results.

Main Methods:

  • Identification of a sample of 38 descriptive or comparative cohort studies.
  • Exclusion of 7 studies due to fundamental design flaws or inadequate reporting.
  • Reproduction of over 1,000 patient characteristics and measures of association for the remaining studies.

Main Results:

  • High accuracy in reproducing patient characteristics (median difference <2%) and measures of association (median difference <0.1).
  • Successful reproduction achieved in the majority of eligible studies.
  • Identified inadequate reporting as a barrier to reproducibility.

Conclusions:

  • Reproducibility of pharmacoepidemiologic studies using healthcare databases is achievable and accurate when fundamental design principles are met.
  • Complete and transparent reporting of study implementation is crucial for ensuring research transparency and reproducibility.
  • Future efforts should focus on improving reporting standards and assessing replicability across different data sources.