Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vaccinations01:51

Vaccinations

51.8K
Overview
51.8K
Cancer Vaccines01:30

Cancer Vaccines

1.1K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Medium for Presumptive Identification of Vibrio parahaemolyticus.

Journal of food protection·2019
Same author

A Medium for Presumptive Identification of Vibrio parahaemolyticus.

Journal of food protection·2019
Same author

Vibrios in the Louisiana gulf coast environment.

Microbial ecology·2013
Same author

Vibrios in the Louisiana gulf coast environment.

Microbial ecology·2013
Same author

LEE-encoded regulator (Ler) mutants elicit serotype-specific protection, but not cross protection, against attaching and effacing E. coli strains.

Vaccine·2007
Same author

Second-generation recombination-based in vivo expression technology for large-scale screening for Vibrio cholerae genes induced during infection of the mouse small intestine.

Infection and immunity·2005
Same journal

Fatal necrotizing otitis externa in a patient with AIDS.

Reviews of infectious diseases·1991
Same journal

Use of the polymerase chain reaction for the specific and direct detection of Clostridium difficile in human feces.

Reviews of infectious diseases·1991
Same journal

A new case of meningitis due to Pasteurella multocida.

Reviews of infectious diseases·1991
Same journal

Disseminated pelvic actinomycosis presenting as metastatic carcinoma: association with the progestasert intrauterine device.

Reviews of infectious diseases·1991
Same journal

Genetically engineered attenuated herpes simplex viruses.

Reviews of infectious diseases·1991
Same journal

Role of altered drug metabolism in virus-drug interactions.

Reviews of infectious diseases·1991
See all related articles

Related Experiment Video

Updated: Feb 11, 2026

Quantifying Vibrio cholerae Colonization and Diarrhea in the Adult Zebrafish Model
08:03

Quantifying Vibrio cholerae Colonization and Diarrhea in the Adult Zebrafish Model

Published on: July 12, 2018

8.9K

Vibrio cholerae vaccines.

J B Kaper1

  • 1Department of Medicine, University of Maryland School of Medicine, Baltimore 21201.

Reviews of Infectious Diseases
|May 1, 1989
PubMed
Summary
This summary is machine-generated.

Developing safe and effective cholera vaccines is ongoing. Promising approaches include live attenuated, killed whole cell plus B subunit, and cloned antigens, with oral administration enhancing mucosal immunity.

More Related Videos

Laboratory Techniques Used to Maintain and Differentiate Biotypes of Vibrio cholerae Clinical and Environmental Isolates
07:58

Laboratory Techniques Used to Maintain and Differentiate Biotypes of Vibrio cholerae Clinical and Environmental Isolates

Published on: May 30, 2017

11.5K
Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview
06:44

Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview

Published on: May 27, 2007

8.0K

Related Experiment Videos

Last Updated: Feb 11, 2026

Quantifying Vibrio cholerae Colonization and Diarrhea in the Adult Zebrafish Model
08:03

Quantifying Vibrio cholerae Colonization and Diarrhea in the Adult Zebrafish Model

Published on: July 12, 2018

8.9K
Laboratory Techniques Used to Maintain and Differentiate Biotypes of Vibrio cholerae Clinical and Environmental Isolates
07:58

Laboratory Techniques Used to Maintain and Differentiate Biotypes of Vibrio cholerae Clinical and Environmental Isolates

Published on: May 30, 2017

11.5K
Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview
06:44

Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview

Published on: May 27, 2007

8.0K

Area of Science:

  • Vaccinology
  • Microbiology
  • Immunology

Background:

  • Cholera remains a significant global health threat, necessitating effective preventive strategies.
  • Current vaccine development focuses on eliciting robust mucosal immunity against Vibrio cholerae.

Purpose of the Study:

  • To review and evaluate current approaches for developing safe and effective cholera vaccines.
  • To assess the progress and challenges in cholera vaccine research.

Main Methods:

  • Review of candidate cholera vaccines including live attenuated strains, killed whole cells with enterotoxin B subunit, and cloned antigens.
  • Analysis of clinical trial data for efficacy and safety of oral cholera vaccines.
  • Evaluation of immune stimulation at the mucosal level.

Main Results:

  • Live attenuated vaccine (CVD103-HgR) showed single-dose efficacy but caused mild diarrhea in 4% of recipients.
  • Killed whole cell plus B subunit vaccine is safe but requires multiple doses for effectiveness.
  • Oral administration is key for stimulating mucosal immunity.

Conclusions:

  • Multiple promising cholera vaccine candidates are under investigation.
  • While challenges remain, progress in vaccine development offers hope for future availability of effective cholera vaccines.