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Updated: Mar 28, 2026

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Recent insights into the development of therapeutics against coronavirus diseases by targeting N protein
Chung-ke Chang1, Shou-Chen Lo2, Yong-Sheng Wang2
1Institute of Biomedical Sciences, Academia Sinica, Nangang, Taipei 11529, Taiwan.
Abstract:
The advent of severe acute respiratory syndrome (SARS) in the 21st century and the recent outbreak of Middle-East respiratory syndrome (MERS) highlight the importance of coronaviruses (CoVs) as human pathogens, emphasizing the need for development of novel antiviral strategies to combat acute respiratory infections caused by CoVs. Recent studies suggest that nucleocapsid (N) proteins from coronaviruses and other viruses can be useful antiviral drug targets against viral infections. This review aims to provide readers with a concise survey of the structural features of coronavirus N proteins and how these features provide insights into structure-based development of therapeutics against coronaviruses. We will also present our latest results on MERS-CoV N protein and its potential as an antiviral drug target.
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