[Hereditary Breast and Ovarian Cancer Syndrome]

Population with hereditary breast and ovarian cancer syndrome, i.e. BRCA1/2 mutation carriers, are at higher risk of developing breast and ovarian cancer as well as other solid tumours such as pancreatic cancer, prostate cancer and melanoma. With the increasing experience, screening recommendations and preventive strategies including prophylactic surgery are being settled. Surveillance of women with hereditary breast cancer syndrome comprises clinical breast examination every six months, breast ultrasound and MRI in patients aged 25 to 29 and MRI and mammography in women aged 30 to 65. Screening of pancreatic cancer should be considered in BRCA1/2 mutation carriers, who have two cases of pancreatic cancer in their family lineage or one first-degree relative with pancreatic cancer. Prostate cancer screening should be recommended to BRCA2 carriers from the age of 40 onwards and it should be considered in BRCA1 carriers as well. Screening for melanoma should be recommended on an individual basis with regards to a family history.