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Updated: Mar 28, 2026

In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding
Published on: May 1, 2020
Inflammation and cutaneous nervous system involvement in hypertrophic scarring
Shao-Hua Li1, Heng-Lian Yang2, Hu Xiao1
1Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.
Abstract:
This study aimed to use a mouse model of hypertrophic scarring by mechanical loading on the dorsum of mice to determine whether the nervous system of the skin and inflammation participates in hypertrophic scarring. Results of hematoxylin-eosin and immunohistochemical staining demonstrated that inflammation contributed to the formation of a hypertrophic scar and increased the nerve density in scar tissue.Western blot assay verified that interleukin-13 expression was increased in scar tissue. These findings suggest that inflammation and the cutaneous nervous system play a role in hypertrophic scar formation.
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