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Relationship of insulin-like growth factor 1 and bone parameters in 7-15 years old apparently, healthy Indian

Veena H Ekbote1, Vaman V Khadilkar1, Anuradha V Khadilkar1

  • 1Growth and Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India.

Indian Journal of Endocrinology and Metabolism
|December 23, 2015
PubMed

Insights

Insulin-like growth factor 1 (IGF-1) is linked to bone area (BA) and lean body mass (LBM) in children. Higher IGF-1 levels correlate with increased bone and muscle development, impacting skeletal growth.

Area of Science:

  • Pediatric endocrinology
  • Bone biology
  • Body composition analysis

Background:

  • Growth hormone (GH) influences bone growth and mineralization via insulin-like growth factor 1 (IGF-1).
  • Understanding the relationship between IGF-1 and skeletal parameters is crucial for pediatric health.

Purpose of the Study:

  • To evaluate the association between serum IGF-1 concentrations and bone/body composition in children.
  • To assess how IGF-1 relates to bone area (BA), lean body mass (LBM), and bone mineral content (BMC).

Main Methods:

  • Cross-sectional study of 119 children (7.3-15.6 years).
  • Anthropometric parameters measured by standard methods.
  • Bone and body composition assessed using dual-energy X-ray absorptiometry (DXA).
  • Serum IGF-1 concentrations measured via ELISA; Z-scores calculated for IGF-1, BA, LBM, and BMC.

Main Results:

  • No significant gender differences in mean age, serum IGF-1 concentrations, or IGF-1 Z-scores.
  • Children with higher IGF-1 Z-scores exhibited greater LBM and BA Z-scores.
  • Mean BMC for age Z-scores showed no significant difference between high and low IGF-1 groups.

Conclusions:

  • Serum IGF-1 levels show a stronger association with bone area (BA) and lean body mass (LBM).
  • IGF-1's effect on bone is primarily related to periosteal bone acquisition and muscle mass development.
Abstract

Keywords:
Bone mineral contentIndian childreninsulin-like growth factor 1

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