Related Experiment Video
Updated: Mar 28, 2026

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
Published on: January 9, 2020
"Controlled, cross-species dataset for exploring biases in genome annotation and modification profiles"
Alison McAfee1, Sarah Michaud1, Leonard J Foster1
1Department of Biochemistry and Molecular Biology, Centre for High-Throughput Biology and Centre for Sustainable Food Systems, University of British Columbia, 2125 East Mall, Vancouver, BC, Canada V6T 1Z4.
Abstract:
Since the sequencing of the honey bee genome, proteomics by mass spectrometry has become increasingly popular for biological analyses of this insect; but we have observed that the number of honey bee protein identifications is consistently low compared to other organisms [1]. In this dataset, we use nanoelectrospray ionization-coupled liquid chromatography-tandem mass spectrometry (nLC-MS/MS) to systematically investigate the root cause of low honey bee proteome coverage. To this end, we present here data from three key experiments: a controlled, cross-species analyses of samples from Apis mellifera, Drosophila melanogaster, Caenorhabditis elegans, Saccharomyces cerevisiae, Mus musculus and Homo sapiens; a proteomic analysis of an individual honey bee whose genome was also sequenced; and a cross-tissue honey bee proteome comparison. The cross-species dataset was interrogated to determine relative proteome coverages between species, and the other two datasets were used to search for polymorphic sequences and to compare protein cleavage profiles, respectively.
More Related Videos
Related Concept Videos
Evolutionary Relationships through Genome Comparisons
Genome Annotation and Assembly
Multi-species Conserved Sequences
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...

