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Automated Multiplex Immunofluorescence Panel for Immuno-oncology Studies on Formalin-fixed Carcinoma Tissue Specimens
Published on: January 21, 2019
[Immunohistology of interstitial lung processes]
G Liebetrau1, G Waldmann, S Henzgen
1Zentralklinik für Herz- und Lungenkrankheiten, Bad Berka.
Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
|June 15, 1989
Summary
Immunohistology on lung tissue biopsies showed positive results in 40.3% of cases. However, this method offered no clear diagnostic, therapeutic, or prognostic value for diffuse pulmonary processes.
Area of Science:
- Pulmonary Medicine
- Immunohistology
- Diagnostic Pathology
Context:
- Diffuse pulmonary processes present diagnostic challenges.
- Transthoracic needle biopsy is a common method for obtaining lung tissue.
- Immunohistologic techniques are increasingly used in pathology.
Purpose:
- To evaluate the utility of immunohistology in diagnosing diffuse pulmonary processes.
- To assess the diagnostic, therapeutic, and prognostic applicability of immunohistology in lung biopsies.
Summary:
- Immunohistologic investigations were conducted on 124 lung tissue samples from patients with diffuse pulmonary processes.
- Positive immunofluorescence was observed in 40.3% of the samples, irrespective of light microscopy findings.
- In exogenic allergic alveolitis, positive results were lower than anticipated (36.8%).
Impact:
- The study concludes that immunohistology provides no significant diagnostic, therapeutic, or prognostic benefits for diffuse pulmonary processes.
- Current immunohistologic methods are not sufficiently applicable for clinical decision-making in these conditions.
