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Galectin-3 Predicts Left Ventricular Remodeling of Hypertension

Yongwei Yao1, Dongli Shen1, Rong Chen1

  • 1Division of Cardiology, Department of Medicine, The Affiliated People's Hospital of Jiangsu University, ZhenJiang City, Jiangsu Province, China.

Journal of Clinical Hypertension (Greenwich, Conn.)
|December 24, 2015
PubMed

Insights

Galectin-3 is a valuable biomarker for detecting early cardiac remodeling in hypertension patients. Higher galectin-3 levels indicate left ventricular remodeling (LVRM) and are linked to hypertension.

Area of Science:

  • Cardiology
  • Biomarkers
  • Hypertension Research

Background:

  • Galectin-3 is implicated in cardiac fibrosis.
  • Early detection of left ventricular remodeling (LVRM) in hypertension is crucial.

Purpose of the Study:

  • To assess galectin-3's utility in identifying early LVRM in hypertensive patients.
  • To explore the correlation between galectin-3 and LVRM predictors.

Main Methods:

  • Study included 107 hypertension patients and 108 controls.
  • Measured serum galectin-3 levels.
  • Utilized multivariate regression and ROC analysis.

Main Results:

  • Galectin-3 levels were significantly higher in hypertensive patients with LVRM.
  • Body mass index and galectin-3 were independent predictors of LVRM.
  • Galectin-3 showed an AUC of 0.698 for LVRM detection with a cutoff of 9.43 ng/mL.

Conclusions:

  • Galectin-3 is independently correlated with LVRM in hypertension.
  • Galectin-3 serves as a valuable biomarker for early cardiac remodeling in hypertension.

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