Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Regulation of Angiogenesis and Blood Supply

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...

Mechanism of Angiogenesis

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...

Master Transcription Regulators

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Reliable and Reusable All-Solid-State Contact-Type Pre-Lithiation Platform for High-Performance All-Solid-State Batteries.

Advanced materials (Deerfield Beach, Fla.)·2026

Same author

Deciphering Interfacial Electronic Interactions Between Iridium Oxide and Ni-Based Supports for High-Current-Density Anion Exchange Membrane Water Electrolysis.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same author

Moisture-tolerant Mg-metal electrodes for practical fabrication of rechargeable Mg batteries.

Nature communications·2026

Same author

Vacancy-Suppressed Garnet Electrolytes for Durable Solid-State Batteries.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

Long Non-Coding RNA MALAT1 Regulates HMOX1 in Sickle Cell Disease-Associated Pulmonary Hypertension.

Cells·2026

Same author

Defining the cellular and molecular identities of histologic subtypes in lung adenocarcinoma.

Experimental hematology & oncology·2026

Search research articles

Related Experiment Video

Updated: Mar 28, 2026

In Vitro Model of Coronary Angiogenesis

In Vitro Model of Coronary Angiogenesis

Published on: March 10, 2020

The ETS Factor, ETV2: a Master Regulator for Vascular Endothelial Cell Development.

Se-Yeong Oh^1,2, Ju Young Kim^1,2,3, Changwon Park^1,2,3,4

¹Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.

Molecules and Cells

|December 24, 2015

Summary

Proper vessel development is crucial for health. This review highlights ETV2, an ETS transcription factor, and its vital role in blood vessel formation during embryogenesis and in adult somatic cells.

Keywords:

ETV2 cell reprogramming endothelial cells transcription factors

More Related Videos

Strategic Endothelial Cell Tube Formation Assay: Comparing Extracellular Matrix and Growth Factor Reduced Extracellular Matrix

Strategic Endothelial Cell Tube Formation Assay: Comparing Extracellular Matrix and Growth Factor Reduced Extracellular Matrix

Published on: August 14, 2016

Micropatterning and Assembly of 3D Microvessels

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

Related Experiment Videos

Last Updated: Mar 28, 2026

In Vitro Model of Coronary Angiogenesis

In Vitro Model of Coronary Angiogenesis

Published on: March 10, 2020

Strategic Endothelial Cell Tube Formation Assay: Comparing Extracellular Matrix and Growth Factor Reduced Extracellular Matrix

Strategic Endothelial Cell Tube Formation Assay: Comparing Extracellular Matrix and Growth Factor Reduced Extracellular Matrix

Published on: August 14, 2016

Micropatterning and Assembly of 3D Microvessels

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

Area of Science:

Developmental Biology
Molecular Biology
Genetics

Background:

Vessel development is critical for embryogenesis and adult homeostasis.
Vessel defects contribute to diseases like cardiovascular disease, tumors, and diabetic retinopathy.

Purpose of the Study:

To review recent advancements in understanding the ETS transcription factor ETV2.
To focus on ETV2's regulatory mechanisms and its role in cell fate determination.

Main Methods:

Literature review of studies on ETV2.
Analysis of ETV2's function in developing mouse embryos.
Examination of ETV2's role in somatic cells.

Main Results:

ETV2 is indispensable for mediating blood vessel development.
ETV2 plays a significant role in cell fate determination during embryogenesis.
ETV2's functions extend to somatic cells.

Conclusions:

ETV2 is a key regulator of vascular development.
Understanding ETV2's mechanisms offers insights into vascular diseases.
Further research into ETV2 is warranted for therapeutic applications.