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Updated: Mar 28, 2026

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
Published on: September 10, 2014
Macrocyclic Metal Complex-DNA Conjugates for Electrochemical Sensing of Single Nucleobase Changes in DNA
Jean-Louis H A Duprey1, James Carr-Smith1, Sarah L Horswell1
1School of Chemistry, University of Birmingham , Edgbaston, Birmingham, West Midlands B15 2TT, U.K.
Abstract:
The direct incorporation of macrocyclic cyclidene complexes into DNA via automated synthesis results in a new family of metal-functionalized DNA derivatives that readily demonstrate their utility through the ability of one redox-active copper(II)-containing strand to distinguish electrochemically between all four canonical DNA nucleobases at a single site within a target sequence of DNA.
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